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COLCHICINE
Colchicine
is used in the treatment of acute gout, including acute
attacks, tophi (collection of uric acid crystals in the tissues,
especially around joints), joint destruction, and uric acid
stones. In acute gout, there is a marked inflammatory response
to the presence of uric acid crystals, causing severe pain,
redness and swelling of the affected joints. Colchicine
is useful in suppressing the inflammation of arthritis in
acute gout.
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| Product |
Ships |
Rx |
Price |
Order |
| Colchicine (Colchicine) 0.6mg 30 Tablets |
USA |
Free |
$44 |
 |
| Colchicine (Colchicine) 0.6mg 60 Tablets |
USA |
Free |
$49 |
|
| Colchicine (Colchicine) 0.6mg 90 Tablets |
USA |
Free |
$54 |
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| Colchicine 120 x Tab(s) 0.5mg |
Global |
Free |
$44.17 |
|
| Colchicine 180 x Tab(s) 0.5mg |
Global |
Free |
$65.18 |
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| Colchicine 60 x Tab(s) 0.5mg |
Global |
Free |
$25.25 |
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Colchicine
Chemical Name : Colchicine
Important Note
The following information is intended to supplement, not substitute
for, the expertise and judgment of your physician, pharmacist or
other healthcare professional. It should not be construed to indicate
that use of the drug is safe, appropriate, or effective for you.
Consult your healthcare professional before using this drug.
Uses
Colchicine is used to treat chronic gout to treat acute flares
of gouty arthritis and to prevent recurrent acute attacks. Colchicine
is also used to treat the inflammation of pseudogout, and other
uncommon diseases, such as familial Mediterranean fever, amyloidosis,
and scleroderma. Colchicine
is not habit forming.
How
to take this medication
Take Colchicine exactly as prescribed by your doctor. If
you do not understand these directions, ask your pharmacist, nurse,
or doctor to explain them to you. Colchicine should be taken
with food.
Side
Effects
The most common side effects of Colchicine involve the stomach
and bowel and are dose related. These include nausea, vomiting,
abdominal pain, and diarrhea. One of the most worrisome side effects
of colchicine is that it can damage the bone marrow causing severe
anemia and seriously low white blood counts, thereby increasing
the risk of infections. All patients taking colchicine long-term
require blood count monitoring. Colchicine can also cause
hair loss, weakness, and nerve irritation.
Precautions
Colchicine can arrest cell division and is avoided in pregnancy
because of possible adverse affects on fetal growth. For
similar reasons, it is generally avoided in children.
Overdose
If overdose is suspected, contact your local poison control center
or emergency room immediately.The following symptoms indicate an
overdose: dizziness; fainting; fast heartbeat.
Missed Dose
If you miss a dose, use it as soon as you remember. If it is near
the time of the next dose, skip the missed dose and resume your
usual dosing schedule. Do not take a double dose to make up for
a missed one.
Storage
Keep this medication in the container it came in, tightly closed,
and out of reach of children. Store it at room temperature and away
from excess heat and moisture (not in the bathroom). Throw away
any medication that is outdated or no longer needed.
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Gout : Who is at riskAnyone can get gout, and the risk factors vary. Fortunately, it is possible to lessen gout's agonizing attacks. Gout can be accurately diagnosed by identifying the characteristic crystals. There are two types of treatment for gout: medications to control attacks of joint pain, and medicines that may help lower levels of uric acid in the body so that attacks occur less frequently or not at all. In some people, however, medication is necessary for the rest of their lives. Weight control, limiting alcohol consumption, and avoiding meats and fish rich in purines are ways to help control gout.
Understanding Gout
Gout causes sudden, mostly severe attacks of pain and tenderness, redness, warmth and swelling in some joints, according to the Arthritis Foundation. It usually affects one joint at a time -- often the big toe. Episodes develop very quickly, and the first episode often occurs at night. Episodes may be caused by drinking too much alcohol, eating too much of certain foods, surgery, sudden illness, crash diets or chemotherapy.
Gout results from a build-up in the body of too much uric acid, which forms crystals that deposit in joints and cause inflammation. Uric acid is a substance that normally forms when the body breaks down waste products called purines. Men older than 40 are at greatest risk, but it can affect anyone of any age. Women with gout usually develop it after menopause. Treatment options include diet, medications, and sometimes surgery.
Induction of nephrotoxic serum nephritis and suppressive effect of Colchicine
Clinically used Colchicine is thought to suppress functions of PMN. Therefore, the therapeutic effect of Colchicine on NTS nephritis was examined. Urinary protein excretion and hyperazotemia were significantly suppressed by treatment with 60 microg kg (-1) of Colchicine. A NTS nephritis model was established, it was found that Colchicine may have a suppressive effect on the development of glomerular nephritis.
Colchicine decreases apoptotic cell death in chronic cyclosporine nephrotoxicity
Colchicine has been shown to prevent kidney injury in chronic cyclosporine nephrotoxicity; however, the mechanisms of its action are undetermined. The purpose of this study was to clarify whether Colchicine prevents cyclosporine-induced kidney injury by decreasing kidney-cell apoptosis. The decreased apoptotic cell death was closely correlated with improved renal tubulointerstitial fibrosis. These findings strongly suggest that a renoprotective effect of Colchicine on cyclosporine-induced nephrotoxicity is coassociated with a decrease in apoptotic cells.
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